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Patents and Publications

Patents and Publications

Core Patents

  • · Patent Applications: 95 cases (international: 59, Korea :36)
  • · Granted Patents: 61 cases (International: 38, Korea: 23)

Holding patent technologies

  • · Highly cancer-specific oncolytic virus
  • · Oncolytic virus with high transgene expression level
  • · Oncolytic virus with improved intratumoral dispersion
  • · Systemically administrable oncolytic virus and nanomaterial complex

Papers (2012~)

  1. In Sik Yun, Eunhye Kang, Hyo Min Ahn, Yong Oock Kim, Dong Kyun Rah, Tai Suk Roh, Won Jai Lee, and Chae-Ok Yun, Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model, Yonsei Medical Journal, 60(9):854-863, 2019 (Co-Corresponding Author).
  2. Thai Minh Duy Le, Bo-Kyeong Jung, Yi Li, Huu Thuy Trang Doung, Thanh Loc Nguyen, Jin Woo Hong, Chae-Ok Yun, and Doo Sung Lee, Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment, Biomaterials Science, Epub ahead of print, 2019 (Co-Corresponding Author)
  3. Dae Yong Lee, Soo-Hwan Lee, Ilkoo Noh, Eonju Oh, Hyunil Ryu, JongHoon Ha, SeongDong Jeong, Jisang Yoo, Tae-Joon Jeon, Chae-Ok Yun, and Yeu-Chun Kim, A Helical Polypeptide-Based Potassium Ionophore Induces Endoplasmic Reticulum Stress-Mediated Apoptosis by Perturbing Ion Homeostasis, Advanced Science, 6(14):1801995, 2019 (Corresponding Author)
  4. Eonju Oh, Bokyung Min, Yan Li, ChunYing Lian, IinWoo hong, Gyeong-min Park, Bitna Yang, Soung Yoo Cho, Yu Kyeong Hwang, and Chae-Ok Yun, Cryopreserved Human Natural Killer Cells Exhibit Potent Antitumor Efficacy against Orthotopic Pancreatic Cancer through Efficient Tumor-Homing and Xytolytic Ability (Running Title: Cryoprserved NK Cells Exhibit Antitumor Effect), Cancers, 11(7). pii: E966, 2019 (Co-Corresponding Author)
  5. Arum Yoon, JinWoo Hong, Yan Li, Ha Chul Shin, Hyunah Lee, Hyun Soo Kim, Chae-Ok Yun, Mesenchymal stem cell-mediated delivery of an oncolytic adenovirus enhances antitumor efficacy in hepatocellular carcinoma, Cancer Research, Epub ahead of print, 2019 (Corresponding Author)
  6. Yan Li, JinWoo Hong, Bo-Kyeong Jung, Eonju Oh and Chae-Ok Yun, Oncolytic Ad co-expressing decorin and Wnt decoy receptor overcomes chemoresistance of desmoplastic tumor through degradation of ECM and inhibition of EMT, Cancer letters, 459:15-29, 2019 (Corresponding Author).
  7. Youjin Na, Joung-Pyo Nam, JinWoo Hong, Eonju Oh, Ha Cheol Shin, Hyun Soo Kim, Sung Wan Kim, and Chae-Ok Yun, Systemic administration of human mesenchymal stromal cells infected with polymer-coated oncolytic adenovirus induces efficient pancreatic tumor homing and infiltration, Journal of Controlled Release, 305:75-88, 2019 (Corresponding Author)
  8. JinWoo Hong, and Chae-Ok Yun, Telomere Gene Therapy: Polarizing Therapeutic Goals for Treatment of Various Diseases, Cells, 28;8(5), 2019 (Corresponding Author)
  9. Dae Yong Lee, Soo-Hwan Lee, Ilkoo Noh, Eonju Oh, Hyunil Ryu, JongHoon Ha, SeongDong Jeong, Jisang Yoo, Tae-Joon Jeon, Chae-Ok Yun, and Yeu-Chun Kim, A Helical Polypeptide-Based Potassium Ionophore Induces Endoplasmic Reticulum Stress-Mediated Apoptosis by Perturbing Ion Homeostasis, Advanced Science, 1801995, 2019 (Co-Corresponding Author)
  10. JinWoo Hong, Chae-Ok Yun, Relaxin gene therapy: A promising new treatment option for various diseases with aberrant fibrosis or irregular angiogenesis, Molecular and Cellular Endocrinology, 487:80-84, 2019 (Corresponding Author)
  11. JongHoon Ha, Dae Yong Lee, Soo-Hwan Lee, Chae-Ok Yun, Yeu-Chun Kim, Development of Apoptosis-inducing Polypeptide via Simultaneous Mitochondrial Membrane Disruption and Ca2+ Delivery, Biomaterials, 197:51-59, 2019 (Co-Corresponding Author)
  12. Eonju Oh, Sukant Garg, Ye Liu, Ran Gao, Chae-Ok Yun, Sunil Kaul and Renu Wadhwa, Identification and functional characterization of anti-metastasis and anti-angiogenic activities of triethylene glycol derivatives, Frontiers in Oncology, 8:552,2018 (Co-Corresponding Author)
  13. Chae-Eun Yang, Seung Jin Moon, Soo Jung Kim, Ju Hee Lee, Chae-Ok Yun, Dae Hyun Lew, Won Jai Lee, Epithelial-mesenchymal transition in keloid tissue, Archives of Plastic Surgery, 45(6):600-601, 2018
  14. Adrianne L. Jenner, Chae-Ok Yun, Arum Yoon, Adelle C. F. Coster & Peter S. Kim, Modeling combined virotherapy and immunotherapy: strengthening the antitumour immune resosne mediated by IL-12 and GM-CSF expression, Letters in Biomathmatics, 5(S1), S99-S116, 2018
  15. Adrianne Jenner, Chae-Ok Yun, Arum Yoon, Peter S. Kim, Adelle C.F. Coster, Modeling heterogeneity in viral-tumour dynamics: the effects of gene-attenuation on viral characteristics, Journal of Theoretical Biology, 454:41-52, 2018
  16. Won Jai Lee, Seung Yong Song, Hyun Roh, Hyo Min Ahn, Youjin Na, Jihee Kim, Ju Hee Lee, and Chae Ok Yun, Profibrogenic effect of high-mobility group box protein-1 in human dermal fibroblasts and its excess in keloid tissues, Scientific Reports, 8(1):8434, 2018. (Co-corresponding author)
  17. Sunil Kaul, Rajkumar Kalra, Anupama Chaudhary, A-Rum Yoon, Priyanshu Bhargava, Amr Omar, Sukant Garg, Chae-Ok Yun, and Renu Wadhwa, CARF Enrichment Promotes Epithelial-mesenchymal Transition via Wnt/β-catenin Signaling: Its Clinical Relevance and Potential as a Therapeutic Target, Oncogenesis, 7(5):39, 2018. (Co-corresponding author)
  18. Chae Eun Yang, Sewoon Choi, Ju Hee Lee, Eun Hye Kang, Dae Hyun Lew, Hyo Min Ahn, Chae-Ok Yun, Won Jai Lee, Scar Remodeling Effect of Alginate Gel-Encapsulated Decoy Wnt receptor (sLRP6E1E2)-Expressing Adenovirus in a Pig Model, International Journal of Molecular Sciences, in press. (Co-corresponding author)
  19. Adrianne Jenner, Chae-Ok Yun, Peter S Kim, Adelle C.F. Coster, Mathematical modelling of the interaction between cancer cells and an oncolytic virus: insights into the effects of treatment protocols, Bulletin of Mathematical Biology, 80(6):1615-1629, 2018
  20. Huda Fadol Yafei, Kaan Uzun; Farayi Musharavati, Erfan Zalnezhad, A.M.S. Hamouda, Chae-Ok Yun, Fadi Jaber, HA/rGO/Pd Nanocomposite Thin Film Coating on SST 304 - Synthesize, Characterization, and Properties Investigations, Journal of Alloys and Compounds, 741:562-574, 2018.
  21. A-Rum Yoon, JinWoo Hong, Minjung Kim, and Chae-Ok Yun, Hepatocellular carcinoma-targeting oncolytic adenovirus overcomes hypoxic tumor microenvironment and effectively disperses through both central and peripheral tumor regions, Scientific Reports, 8(1):2233, 2018. (Corresponding Author)
  22. Lang Yoo, A-Rum Yoon, Chae-Ok Yun, and Kwang Chul Chung, Covalent ISG15 conjugation to CHIP promotes its ubiquitin E3 ligase activity and inhibits lung cancer cell growth in response to type I interferon, Cell Death and Disease, 9(2):97, 2018.
  23. Eonju Oh, JinWoo Hong, Oh-Joon Kwon, and Chae-Ok Yun, A hypoxia- and telomerase-responsive oncolytic adenovirus expressing secretable trimeric TRAIL triggers tumour-specific apoptosis and promotes viral dispersion in TRAIL-resistant glioblastoma, Scientific Reports. 8(1):1420, 2018. (Corresponding Author)
  24. Jin Woo Hong and Chae-Ok Yun, Emergence of Ad-mediated combination therapy against cancer: What to expect?, Current Cancer Drug Target, 18(2):139-152, 2018. (Corresponding Author).
  25. Won Jai Lee, Jung-Sun Lee, Hyo Min Ahn, Youjin Na, Ju Hee Lee, Chae-Eun Yang, Jin Woo Hong, and Chae-Ok Yun, Decoy Wnt receptor (sLRP6E1E2)-expressing adenovirus induces anti-fibrotic effect via inhibition of Wnt and TGF-β signaling, Scientific Reports., 7(1):15070, 2017. (Corresponding Author)
  26. A-Rum Yoon, JinWoo Hong, and Chae-Ok Yun, Adenovirus-mediated decorin expression induces cancer cell death through activation of p53 and mitochondrial apoptosis, Oncotarget, 8(44):76666-76685, 2017. (Corresponding Author)
  27. Won Jai Lee, Hyo Min Ahn, Youjin Na, Renu Wadhwa, JinWoo Hong, and Chae-Ok Yun, Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids, Scientific Reports. 7(1):12957, 2017. (Corresponding Author)
  28. Yan Li, JinWoo Hong, Joung-Eun Oh, A-Rum Yoon, and Chae-Ok Yun, Potent antitumor effect of tumor microenvironment-targeted oncolytic adenovirus against desmoplastic pancreatic cancer, International Journal of Cancer, 142(2):392-413, 2018. (Corresponding Author)
  29. Adel Galal El-Shemi, Ahmad Mohammed Ashshi, Eonju Oh, Bo-Kyeong Jung, Mohammed Basalamah, Aiman Alsaegh, and Chae-Ok Yun, Efficacy of combining ING4 and TRAIL genes in cancer-targeting gene virotherapy strategy: First evidence in preclinicalhepatocellular carcinoma, Gene Therapy, 25(1):54-65, 2018 (Corresponding Author)
  30. Bo-Kyeong Jung, Eonju Oh, JinWoo Hong, Yunki Lee, Ki Dong Park, and Chae-Ok Yun, A hydrogel matrix prolongs persistence and promotes specific localization of an oncolytic adenovirus in a tumor by restricting nonspecific shedding and an antiviral immune response, Biomaterials, 147:26-38, 2017. (Corresponding Author)
  31. Bok ki Jung, Won Jai Lee, Eunhye Kang, Hyo Min Ahn, Yong Oock Kim, Dong Kyun Rah, Chae-Ok Yun, and In Sik Yun, Effect of relaxin expressing adenovirus on scar remodelling: Preliminary study, Archives of Craniofacial Surgery. 18(1):9-15, 2017.
  32. Dayananda Kasala, Soo-Hwan Lee, JinWoo Hong, Joung-Woo Choi, Kihoon Nam, Yoon Ho Chung, Sung Wan Kim, and Chae-Ok Yun, Synergistic antitumor effect mediated by a paclitaxel-conjugated polymeric micelle-coated oncolytic adenovirus, Biomaterials, 145:207-222, 2017. (Corresponding Author)
  33. DaeYong Lee, Soo-Hwan Lee, Youjin Na, Ilkoo Noh, JongHoon Ha, Jisang Yoo, Hyun Bae Bang, Jong Hyun Park, Ki Jun Jeong, Chae-Ok Yun. and Yeu-Chun Kim, Conformation-switchable helical polypeptide eliciting selective pro-apoptotic activity for cancer therapy, Journal of Controlled Release, 264:24-33, 2017. (Co-Corresponding Author)
  34. Min Jun Kim, Zahid Alam, Eon Ju Oh, Yong Hwa Hwang, Yong-kyu Lee, Chae-Ok Yun, Dong Yun Lee, Synergism of highly transdusable adenovirus encoding heme oxygenase 1 gene and low-dose immunosuppressants for successful outcomes of xenotransplanted pancreatic islet, Journal of Industrial and Engineering Chemistry, 47: 202-213, 2017. (Co-corresponding Author).
  35. Taeyoung Koo, A-Rum Yoon, Hee-Yeon Cho, Sangsu Bae, Chae-Ok Yun, and Jin-Soo Kim, Selective disruption of the mutant allele by CRISPR RNA for efficient tumor regression, Nucleic Acids Research, 45(13):7897-7908, 2017. (Co-corresponding Author).
  36. A-Rum Yoon, Dayananda Kasala, Jinwoo Hong, Chae-Ok Yun, Safety profile of EGFR-targeted hybrid vector system composed of PAMAM dendrimer and oncolytic adenovirus, Journal of Thoracic Disease, 9(3):E335-E336, 2017, Letter to the Editor. (Corresponding Author)
  37. Eonju Oh, Jung-Eun Oh, JinWoo Hong, YoonHo Chung, Yunki Lee, Ki Dong Park, Sungwan Kim, Chae-Ok Yun, Optimized biodegradable polymeric reservoir-mediated local and sustained co-delivery of dendritic cells and oncolytic adenovirus co-expressing IL-12 and GM-CSF for cancer immunotherapy, Journal of Controlled Release, 259:115-127. (Corresponding Author).
  38. Kyung Hee Jung, Il-Kyu Choi, Hee-Seung Lee, Hong Hua Yan, Mi Kwon Son, Hyo Min Ahn, JinWoo Hong, Chae-Ok Yun, Soon-Sun Hong, Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer, Cancer Letters, 396:155-166, 2017. (Co-Corresponding Author).
  39. Min Jun Kim, Zahid Alam, Eon Ju Oh, Yong Hwa Hwang, Yong-kyu Lee, Chae-Ok Yun, Dong Yun Lee, Synergism of highly transdusable adenovirus encoding heme oxygenase 1 gene and low-dose immunosuppressants for successful outcomes of xenotransplanted pancreatic islet, Journal of Industrial and Engineering Chemistry, 47: 202-213, 2017. (Co-corresponding Author).
  40. Chae-Ok Yun, Priyanshu Bhargava, Youjin Na, Jung-Sun Lee, Jihoon Ryu, Sunil Kaul, and Renu Wadhwa, Relevance of mortalin to cancer cell stemness and cancer therapy, Scientific Reports. 7:42016, 2017. (First Author)
  41. Eonju Oh, Il-Kyu Choi, Jin Woo Hong, and Chae-Ok Yun, Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression for antitumor effects in a weakly immunogenic tumor model, Oncotarget, 8(3):4730-4746, 2017. (Corresponding Author).
  42. Hyo Min Ahn, JinWooHong, Chae-Ok Yun, Oncolytic adenovirus coexpressing interleukin-12 and shVEGF restores antitumor immune function and enhances antitumor efficacy, Oncotarget, 7(51):84965-84980, 2016. (Corresponding Author).
  43. Jung, Bo-Kyeong ; Lee, Yeon Kyung; Hong, Jinwoo; Ghandehari, Hamidreza; Yun, Chae-Ok, Mild Hyperthermia induced by Gold Nanorod-Mediated Plasmonic Photothermal Therapy Enhances Transduction and Replication of Oncolytic Adenoviral Gene Delivery, ACS Nano, 10(11):10533-10543. 2016. (Corresponding Author)
  44. Yoon Ok Jang, Mee-Yon Cho, Chae-Ok Yun, Kyu-Sang Park, Seung-Kuy Cha, Sei Jin Chang, Moon Young Kim, Yoo Ri Lim, Sang Ok Kwon, Soon Koo Baik, Effect of Function-Enhanced Mesenchymal Stem Cells Infected With Decorin-Expressing Adenovirus on Hepatic Fibrosis,, Stem Cell Translational Medicine, 5(9):1247-56, 2016.
  45. Dayananda Kasala, A-RumYoon, Jinwoo Hong, SungWanKim, and Chae-Ok Yun, Evolving lessons on nanomaterial-coated viral vectors for local and systemic gene therapy, Nanomedicine, 11(13):1689-713, 2016. (Corresponding Author)
  46. Adel Galal El-shemi, Ahmad Mohammed Ashshi, Youjin Na, Yan Li, Mohammed A Basalamah, Faisal Ahmad Al-Allaf, Eonju Oh, Bo-Kyeong Jung, Chae-Ok Yun, Combined therapy with oncolytic adenoviruses encoding TRAIL and IL-12 genes markedly suppressed human hepatocellular carcinoma both in vitro and in an orthotopic transplanted mouse model, submitted to Journal of Experimental & Clinical Cancer Research, 35(1):74, 2016. (Corresponding Author)
  47. Young Sook Lee, Joung-Woo Choi, Jung-Eun Oh, Chae-Ok Yun, Sung Wan Kim, Human Relaxin gene expression delivered by bioreducible dendrimer polymer for post-infarct cardiac remodeling in rats, Biomaterials, 97:164-185, 2016 (Corresponding Author)
  48. Wadhwa, Didik Priyandoko, Ran Gao, Nashi Widodo, Nupur Nigam, Ling Li, Hyo Min Ahn, Chae-Ok Yun, Nobuhiro Ando, Christian Mahe, Sunil C. Kaul, Stress chaperone mortalin regulates human melanogenesis, Cell Stress and Chaperones, 21:631-644, 2016. Selected for Cover Page
  49. A-Rum Yoon, Jinwoo Hong, Sung Wan Kim, and Chae-Ok Yun, Redirecting adenovirus tropism by genetic, chemical, and mechanical modification of the adenovirus surface for cancer gene therapy, Expert Opinion on Drug Delivery, 13(6):843-58, 2016. (Corresponding Author)
  50. Youjin Na, Sunil C Kaul, Jihoon Ryu, Jung-Sun Lee. Hyo Min Ahn, Zeenia Kaul, Rajkumar S Kalra, Ling Li, Nashi Widodo, Chae-Ok Yun, and Renu Wadhwa, Stress Chaperone Mortalin contributes to epithelial-Mesenchymal Transition and Cancer Metastasis, Cancer Research, 76(9): 2754-2765, 2016 (Co-Corresponding Author)
  51. A-Rum Yoon, Dayananda Kasala, Yan Li, Jinwoo Hong, Wonsig Lee, Soo-Jung Jung, and Chae-Ok Yun, Antitumor effect and safety profile of systemically delivered oncolytic adenovirus complexed with EGFR-targeted PAMAM-based dendrimer in orthotopic lung tumor model, Journal of Controlled Release, 231:2-16, 2016 (Corresponding Author)
  52. Dae-Hwan Park, Jaeyong Cho, Oh-Joon Kwon, Chae-Ok Yun, and Jin-Ho Choy, Biodegradable Inorganic Nanovector: Passive vs. Active Tumor Targeting in siRNA Transportation, Angewandte Chemie, 55(14):4582-6, 2016.
  53. Goeun Choi, Piao Huiyan, Zeid A. Alothman, Ajayan Vinu, Chae-Ok Yun. Jin-Ho Choy, Anionic clay as the drug delivery vehicle: Tumor targeting function of LDH-MTX nanohybrid in C33A orthotopic cervical cancer model, International Journal of Nanomedicine, 11:337-348, 2016.
  54. Yangjin Kim, Avner Friedman, Eugene Kashdan, Urszula Ledzewicz, and Chae-Ok Yun, Application of ecological and mathematical theory to cancer: New challenges. Mathematical Biosciences and Engineering, 12(6):1-4. 2015. (Corresponding Author).
  55. Joanna Wares, Joseph J. Crivelli, Chae-Ok Yun, Il-Kyu Choi, Jana L. Gevertz, Peter S. Kim, Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections, Mathematical Biosciences and Engineering, 12(6):1237-1256. 2015. (Co-Corresponding author)
  56. Ja Kyung Kim, Jung Il Lee, Yong-Han Paik, Chae-Ok Yun, Hye Young Chang, Su Yeon Lee, Kwan Sik Lee, A single adenovirus-mediated relaxin delivery attenuates established liver fibrosis in rats, Journal of Gene Medicine, 18(1-3):16-26. 2016.
  57. Boram Min, Hyo Jin Park, Sungwoon Lee, Yan Li, Jung-Min Choi, Joo Yong Lee, Jin Kim, Young Deuk Choi, Young-Guen Kwon, Han-Woong Lee, Suk-Chul Bae, Chae-Ok Yun, and Kwang Chung, CHIP-mediated Degradation of Transglutaminase 2 Negatively Regulates Tumor Growth and Angiogneesis in Renal Cancer, Oncogene, 35(28):3718-3728. 2016.
  58. A-Rum Yoon, Sung Wan Kim, and Chae-Ok Yun, Armed Oncolytic Adenoviruses and Polymer-shielded Nanocomplex for Systemic Delivery, Current Cancer Therapy Reviews, 11(3);136-153, 2015. (Corresponding Author).
  59. A-Rum Yoon, Sung Wan Kim, and Chae-Ok Yun, Armed Oncolytic Adenoviruses and Polymer-shielded Nanocomplex for Systemic Delivery, Current Cancer Therapy Reviews, 11(3);136-153, 2015. (Corresponding Author)
  60. Seung-Hwan Lee, Dong-Young Kim, Feifeng Jing, Hyesoon Kim, Chae-Ok Yun, Deok-Jong Han, and Eun Young Choi, Del-1 overexpression potentiates lung cancer cell proliferation and invasion, Biochem Biophys Res Commun., 468(1-2):92-8, 2015.
  61. Youjin Na, Joung-Woo Choi, Dayananda Kasala, Jin Woo Hong, Eonju Oh, Yan Li, Soo-Jung Jung, Sung Wan Kim, and Chae-Ok Yun, Potent antitumor effect of neurotensin receptor-targeted oncolytic adenovirus co-expressing decorin and Wnt antagonist in an orthotopic pancreatic tumor model, Journal of Controlled Release, 220 (Pt B):766-82, 2015. (Corresponding Author).
  62. Yang Y, Xu WW, Neill T, Hu Z, Wang CH, Xiao X, Stock S, Guise T, Yun CO, Brendler CB, Iozzo RV, Seth P., Systemic Delivery of an Oncolytic Adenovirus Expressing Decorin for the Treatment of Breast Cancer Bone Metastases, Human Gene Therapy, 26(12):813-25, 2015.
  63. Sah SK, Park KH, Yun CO, Kang KS, Kim TY., Effects of human mesenhymal stem cells transduced with superoxide dismutase on imiquimod-induced psoriasis-like skin inflammation in mice, Antioxid Redox Signal, 24(5):233-248, 2016.
  64. Joung-Woo Choi, Young Sook Lee, Chae-Ok Yun, and Sung Wan Kim, Polymeric oncolytic adenovirus for cancer gene therapy, Journal of Controlled Release, 219:181-191, 2015 (Corresponding Author)
  65. Joung-Woo Choi, Hyun Ah Kim, Kihoon Nam, Youjin Na, Chae-Ok Yun, Sung Wan Kim, Hepatoma targeting peptide conjugated bio-reducible polymer complexed with oncolytic adenovirus for cancer gene therapy, submitted to Journal of Controlled Release, 220(Pt B):691-703, 2015.
  66. A-Rum Yoon, Jinwoo Hong, Chae-Ok Yun, A vesicular stomatitis virus glycoprotein epitope-incorporated oncolytic adenovirus overcomes CAR-dependency and shows markedly enhanced cancer cell killing and suppression of tumor growth, Oncotarget, 6(33):34875-91, 2015 (Corresponding Author).
  67. Joung-Woo Choi, Kasala Dayananda, Soo-Jung Jung, Soo-Hwan Lee, Donghyun Kim, Jun Hu, You Han Bae, and Chae-Ok Yun, Enhanced anti-tumor efficacy and safety profile of tumor microenvironment-responsive oncolytic adenovirus nanocomplex by systemic administration, Acta Biomaterialia, S1742-7061(15)30108-2, 2015 (Corresponding Author).
  68. Won Jai Lee, Ju Hee Lee, Hyo Min Ahn, Seung Yong Song, Yong Oock Kim, Dae Hyun Lew, Chae-Ok Yun, Heat Shock Protein 90 Inhibitor Decreases Collagen Synthesis of Keloid Fibroblasts and Attenuates the Extracellular Matrix on the Keloid Spheroid Model, Plastic and Reconstructive Surgery, 136(3):328e-337e, 2015. (Corresponding Author).
  69. Jeon YR, Ahn HM, Choi IK, Yun CO, Rah DK, Lew DH, Lee WJ, Hepatocyte growth factor-expressing adenovirus upregulates matrix metalloproteinase-1 expression in keloid fibroblasts. Int J Dermatol. 55(3):356-361, 2016.
  70. Joung-Woo Choi, Ji Won Park, Youjin Na, Soo-Jung Jung, June Kyu Hwang, Dongho Choi, Kyeong Geun Lee, and Chae-Ok Yun. Using a magnetic field to redirect an oncolytic adenovirus complexed with iron oxide augments gene therapy efficacy, Biomaterials, 65:163-174, 2015 (Corresponding Author).
  71. Joung-Woo Choi, Jaesung Kim, Quang Bui, Yi Li, Chae-Ok Yun, Doo Sung Lee, Sung Wan Kim, Tuning surface charge and PEGylation of biocompatible polymers for efficient delivering of nucleic acid or adenoviral vector, Bioconjugate Chemistry, 26, 1818−1829, 2015. (Co-Corresponding Author)
  72. Joung-Pyo Nam, Seong-Cheol Park, Kyeong-Jae Lee, Joung-Woo Choi, Chae-Ok Yun, Mi-Kyeong Jang, Jae-Woon Nah, Targeting delivery of tocopherol and doxorubicin grafted-chitosan polymeric micelles for cancer therapy: in vitro and in vivo evaluation, Colloids and Surfaces B: Biointerfaces, 133:254–262, 2015.
  73. Joung-Woo Choi, Joung-Pyo Nam, Kihoon Nam, Young Sook Lee, Chae-Ok Yun, and Sung Wan Kim, Oncolytic adenovirus coated with multidegradable bioreducible core-cross-linked polyethyleneimine for cancer gene therapy, Biomacromolecules, (Co-corresponding Author), 6(7):2132-43, 2015.
  74. Peter S. Kim, Joseph J. Crivelli, Il-Kyu Choi, Chae-Ok Yun, Joanna R.Wares, Quantitative impact of immunomodulation versus oncolysis with cytokine-expressing virus therapeutics, Mathematical Biosciences and Engineering, 12(4):841-858, 2015. (Co-Corresponding author)
  75. Il-Kyu Choi, Hyewon Shin, Eonju Oh, Ji Young Yoo, June Kyu Hwang, Kyungsub Shin, De-Chao Yu, and Chae-Ok Yun, Potent and long-term antiangiogenic efficacy mediated by FP3-expressing oncolytic adenovirus, International Journal of Cancer, 137(9):2253-69, 2015 (Corresponding Author).
  76. Weon Sup Lee, Bo-Jeong Pyun, Sung-Woo Kim, Sang Ryeol Shim, Ji-Young Yoo, Younggeon Jin, Juyoun Jin, Young-Guen Kwon, Chae-Ok Yun, Do-Hyun Nam, Keunhee Oh, Dong-Sup Lee, Sang Hoon Lee, Jin-San Yoo, "TTAC-0001, a human monoclonal antibody targeting VEGFR-2/KDR, blocks tumor angiogenesis, mAbs, 3;7(5):957-968, 2015.
  77. Se-Hui Jung, Joung-Woo Choi, Chae-Ok Yun, Sun Hwa Kim, Ick Chan Kwon, and Hamidrez Ghandehari, Direct observation of SELP interactions with adenoviruses and elastase, Molecular Pharmaceutics., 12(5):1673-9, 2015.
  78. Won Jain Lee, Hyo-Min Ahn, Hyun Roh, Youjin Na, Il-Kyu Choi, Ju Hee Lee, Yong Oock Kim, Dae Hyun Lew, Chae-Ok Yun, Decorin-expressing adenovirus decreases collagen synthesis and upregulates MMP expression in keloid fibroblasts and keloid spheroids, Experimental Dermatology, 24(8):591-7. 2015 (Corresponding Author).
  79. Won Jai Lee, Ji Hun Park, Jung U Shin, Hyun Noh, Dae Hyun Lew, Woo Ick Yang, Chae Ok Yun, Kwang Hoon Lee, and Ju Hee Le, Endothelial-to-Mesenchymal Transition induced by Wnt3a in Keloid pathogenesis, Wound Repair and Regeneration, 23(3):435-42. 2015.
  80. Jung-Sun Lee, Eonju Oh, Ji Young Yoo, Kyeong Sook Choi, Mi Jin Yoon, Chae-Ok Yun, Adenovirus expressing dual c-Met-specific shRNA exhibits potent antitumor effect through autophagic cell death accompanied by senescence-like phenotypes in glioblastoma cells, Oncotarget, 6(6):4051-65, 2015 (Corresponding Author).
  81. Renu Wadhwa, Jihoon Ryu, Hyo Min Ahn, Nishant Saxena, Chae-Ok Yun, and Sunil C. Kaul, Functional Significance of Point Mutations in Stress Chaperone Mortalin and Their Relevance to Parkinson Disease, Journal of Biological Chemistry, 290(13):8447-56, 2015. (Co-Corresponding author).
  82. Young Sook Lee, Kwang Suk Lim, Jung-Eun Oh; Arum Yun, Wan Seok Joo, Hyun Soo Kim, Chae-Ok Yun, Sung Wan Kim, Development of porous PLGA/PEI1.8k biodegradable microspheres for the delivery of Mesenchymal Stem Cells (MSCs), Journal of Controlled Release. 205:128-33, 2015.
  83. Choi JW, Jung SJ, Kasala D, Hwang JK, Hu J, Bae YH, Yun CO, pH-sensitive oncolytic adenovirus hybrid targeting acidic tumor microenvironment and angiogenesis, Journal of Controlled Release. 205:134-43, 2015 (Corresponding Author).
  84. Chang Yoon Moon, Joung-Woo Choi, Dayananda Kasala, Soo-Jung Jung, Sung Wan Kim, and Chae-Ok Yun, Dual tumor targeting with pH-sensitive and bioreducible polymer-complexed oncolytic adenovirus, Biomaterials, 41:53-68, 2015 (Corresponding Author).
  85. Dong Kyun Rah, In Sik Yun, Chae-Ok Yun, Sae Bin Lee, and Won Jai Lee, Gene therapy using hepatocyte growth factor expressing adenovirus improves skin flap survival in a rat model, J Korean med Sci, 29:S228-236, 2014.
  86. Soo-Jung Jung, Dayananda Kasala, Joung-Woo Choi, Soo-Hwan Lee, June Kyu Hwang, Sung Wan Kim, and Chae-Ok Yun, Safety profiles and antitumor efficacy of oncolytic adenovirus coated with bioreducible polymer in the treatment of CAR negative tumor model, Biomacromolecules, 16(1):87-96, 2015 (Corresponding Author).
  87. Ran Gao, Navjot Shah, Jung-Sun Lee, Shashank P. Katiyar, Ling Li, Eonju Oh, Durai Sundar, Chae-Ok Yun, Renu Wadhwa, and Sunil C. Kaul, Withanone-Rich Combination of Ashwagandha Withanolides Restricts Metastasis And Angiogenesis Through hnRNP-K, Molecular Cancer Therapeutics. 13(2):2930-40, 2014. (Co-Corresponding author).
  88. Jihoon Ryu, Zeenia Kaul, A-Rum Yoon, Ye Liu, Youjin Na, Ran Gao, Tomoko Yaguchi, Il-Kyu Choi, Chae-Ok Yun, Sunil C. Kaul and Renu Wadhwa. Identification and Functional Characterization of Nuclear Mortalin in Human Carcinogenesis, Journal of Biological Chemistry, 289(36):24832-44, 2014. (Co-Corresponding author)
  89. Se-Hui Jung, Joung-Woo Choi, Chae-Ok Yun, Ji Young Yhee, Robert Price, Sun Hwa Kim, Ick Chan Kwon, and Hamidreza Ghandehari, Sustained local delivery of oncolytic shRNA adenoviruses for treatment of head and neck cancer, Journal of Gene Medicine, 16(5-6):143-52, 2014.
  90. Lee JH, Park MJ, Kim JK, Kim YC, Kim TH, Park MS, Yu JS, Kim KW, Kim YB, Kim SH, Shim W, Kim D, Yun CO, Ahn SH, Assessment of angiogenesis of hepatocellular carcinoma using dynamic contrast enhanced MR and histopathologic correlation in an experimental rat model, Hepatogastroenterology, 61(130):447-52, 2014.
  91. Shin JU, Park J, Lee JH, Lee KH, Kim YO, Yun CO, Lee WJ, Extramarginal excision is preferable for hypertrophic scars, International Journal of Dermatology, 53(9):1138-1144, 2014.
  92. Choi WI, Kim MY, Jeon BN, Koh DI, Yun CO, Li Y, Lee CE, Oh J, Kim K, Hur MW, Role of Promyelocytic Leukaemia Zinc Finger (PLZF) in cell proliferation and cyclin dependent kinase inhibitor 1A (p21WAF/CDKN1A) gene repression, Journal of Biological Chemistry, 289(27):18625-18640, 2014.
  93. Cho-Hee Lee, Dayananda Kasala, Youjin Na, Sung Wan Kim, Jihoon Jeong, and Chae-Ok Yun. Enhanced therapeutic efficacy of an adenovirus-PEI-bile-acid complex in tumors with low coxsackie and adenovirus receptor expression, Biomaterials, 35(21):5505-5516, 2014 (Corresponding Author).
  94. Goeun Choi, Oh-Joon Kwon, Yeonji Oh, Dae-Hwan Park, Chae-Ok Yun, Jin-Ho Choi, Inorganic Nanovehicle Targets Tumor in an Orthotopic Breast Cancer Model, Scientific Reports, 4:4430, 2014. (Co-Corresponding author)
  95. Mi Jin Yoon, You Jung Kang, Joo Ahn Lee, In Young Kim, Ji Hae Park, Bun Yeoul Lee, Hak Sung Kim, Soon-Ai Kim, A-Rum Yoon, Chae-Ok Yun, Eun-Yeong Kim, Kiho Lee, In Ah Kim, Mi Ae Kim, and Youngsoo Lee, Kyeong Sook Choi, Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin, Cell Death and Disease, 5:e1112, 2014.
  96. Jaesung Kim, Hye Yeong Nam, Jung Woo Choi, Chae-Ok Yun and Sung Wan Kim, Efficient lung orthotopic tumor-growth suppression of oncolytic adenovirus complexed with RGD-targeted bioreducible polymer, Gene Therapy, 21(5):476-483, 2014.
  97. Kasala Dayananda, Joung Woo Choi, Sung Wan Kim, and Chae-Ok Yun, Utilizing adenovirus vectors for gene delivery in cancer, Expert Opinion on Drug Delivery, 11(3):379-392, 2014 (Corresponding Author).
  98. Sung Hoon Choi, Oh-Joon Kwon, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim, Simon Weonsang Ro, Kyung Sik Kim5,6, Jeon Han Park7, Seungtaek Kim, Chae-Ok Yun, and Kwang-Hyub Han, Inhibition of tumour angiogenesis and growth by small hairpin HIF-1α and IL-8 in hepatocellular carcinoma, Liver International, 34(4):632-642, 2014.
  99. Young-Mi Kang, Yun-Rak Choi, Chae-Ok Yun, Jin-Oh Park, Kyung-Soo Suk, Hak-Sun Kim, Moon-Soo Park, Byung-Ho Lee, Hwan-Mo Lee, Seong-Hwan Moon, Down regulation of collagen synthesis and matrix metalloproteinase expression in myofibroblasts from Dupuytren nodule using adenovirus-mediated relaxin gene therapy, Journal of Orthopaedic Research, 32(4):515-23, 2014.
  100. Eun-Kyung Kim, Hyung-Seok Seo, Min-Ji Chae, In-Su Jeon, Bo-Yeoung Song, Young-Jun Park, Hyo Min Ahn, Chae-Ok Yun, and Chang-Yuil Kang, Enhanced antitumor immunotherapeutic effect of B cell-based vaccine transduced with modified adenoviral vector containing type 35 fiber structures, Gene Therapy, 21(1):106-14, 2014.
  101. Kyoung-Jae Won, Joo-Young Im, Chae-Ok Yun, Kyung-Sook Chung, Young-Joo Kim, Jung-Sun Lee, Young-Jin Jung, Bo-Kyung Kim, Kyung-Bin Song, Young-Ho Kim, Ho-Kyung Chun, Kyeong Eun Jung, Moon-Hee Kim, Misun Won, Human noxin is an anti-apoptotic protein in response to DNA damage of A549 non-small cell lung carcinoma. International Journal of Cancer, 134(11):2595-2604, 2014.
  102. Hongryeol Park, Hyei Yoon Jung, Hyun-Jung Choi, Dong Young Kim, Ji-Young Yoo, Chae-Ok Yun, Jeong-Ki Min, Young-Myoung Kim, Young-Guen Kwon, Distinct roles of DKK1 and DKK2 in tumor angiogenesis. Angiogenesis, 17(1):221-34, 2014.
  103. Il-Kyu Choi, Robert Strauss, Maximilian Richter, Chae-Ok Yun, Andre Lieber, Strategies to increase drug penetration in solid tumors, Frontiers in Oncology, 3: 1-18, article 193, 2013, (Co-Corresponding author)
  104. Il-Kyu Choi, Yan Li, Eonju Oh, Jaesung Kim, and Chae-Ok Yun, Oncolytic adenovirus expressing IL-23 and p35 elicits IFN-γ -and TNF-a-co-producing Tcell-mediated antitumor immunity, Plos One, 8(7):e67512, 2013 (Corresponding Author).
  105. Lim SA, Kim TJ, Lee JE, Sonn CH, Kim K, Kim J, Choi JG, Choi IK, Yun CO, Kim JH, Yee C, Kumar V, Lee KM., Ex Vivo Expansion of Highly Cytotoxic Human NK Cells by Cocultivation with Irradiated Tumor Cells for Adoptive Immunotherapy. Cancer Research, 15;73(8):2598-2607, 2013.
  106. Oh-Joon Kwon, Eunah Kang, Joung-Woo Choi, Sung Wan Kim, and Chae-Ok Yun, Therapeutic targeting of chitosan-PEG-folate-complexed oncolytic adenovirus for active and systemic cancer gene therapy Journal of Controlled Release, Journal of Controlled Release, 169(3):257-265, 2013 (Corresponding Author).
  107. Jaesung Kim, Yi Li, Sung Wan Kim, Doo Sung Lee, and Chae-Ok Yun, Therapeutic efficacy of a systemically delivered oncolytic adenovirus - biodegradable polymer complex, Biomaterials, 34:4622-4631, 2013 (Corresponding Author).
  108. Joung-woo Choi, Eunah Kang, Oh-Joon Kwon, Tae Jin Yun, Hong-kwan park, Pyung-hwan kim, Sung Wan Kim, and Jung-Hyun Kim, Chae-Ok Yun, Local sustained delivery of oncolytic adenovirus with injectable alginate gel for cancer virotherapy, Gene Therapy, 20(9):880-892, 2013 (Corresponding Author).
  109. Kim MK, Jeon BN, Koh DI, Park SY, Yun CO, Hur MW, Regulation of the Cyclin-dependent kinase inhibitor 1A gene (CDKNIA) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding, J Biol Chem, 288(10):7053-7064, 2013.
  110. Il-Kyu Choi and Chae-Ok Yun, Recent developments in oncolytic adenovirus-based immunotherapeutic agents for use against metastatic cancers, Cancer Gene Therapy, 20(2):70-76, 2013 (Corresponding Author).
  111. Won Jai Lee, Il-Kyu Choi, Ju Hee Lee, Yong Oock Kim, Chae-Ok Yun, A novel three-dimensional model system for keloid study: Organotypic multicellular keloid spheroids, Wound repair and regeneration, 21(1):155-165, 2013 (Corresponding Author).
  112. J Park, K Singha, S Son, J Kim, R Namgung, C-O Yun, and W J Kim, A review of RGD-functionalized non-viral gene delivery vectors for cancer therapy, Cancer Gene Therapy, 19(11):741-748, 2012.
  113. Hojeong Ryu, Kyujung Kim, Kyungjae Ma, Wonju Lee, Jeongwoo Choi, Chae-Ok Yun, and Donghyun Kim, Enhanced detection of ambient adenovirus based on nanoisland-based localized surface plasmon resonance, Biosensors and Bioelectronics, 41:249–255, 2013.
  114. Won Jai Lee, Ju Hee Lee, Il-Kyu Choi, Beyoung-Yun Park, Yong Oock Kim, Dong Kyun Rah, Chae-Ok Yun, Relaxin-expressing adenovirus decreases collagen synthesis and up-regulates matrix metalloproteinase expression in Keloid fibroblasts. Plastic and Reconstructive Surgery. 130(3):407e-417e, 2012 (Corresponding Author).
  115. Jui Seo, Chae-Ok Yun, Oh-Joon Kwon, Eun-Jin Choi, Jae-Young Song, Inho Choi, Kyung-Hyun Cho, A proteoliposome containing apolipoprotein A-I mutant (V156K) enhances rapid tumor regression activity of human origin oncolytic adenovirus in tumor-bearing zebrafish and mice. Mol. Cell, 34(2):143-148, 2012.
  116. Jung-Sun Lee, Man-Wook Hur, Seong Kyung Lee, Won-Il Choi, Young-Guen Kwon, Chae-Ok Yun, A Novel sLRP6E1E2 inhibits canonical Wnt signaling, epithelial-to-mesenchymal transition, and induces mitochondria-dependent apoptosis in lung cancer, Plos One, 7(5):e36520, 2012 (Corresponding Author).
  117. Koom WS, Park SY, Kim W, Kim M, Kim JS, Kim H, Choi IK, Yun CO, Seong J, Combination of Radiotherapy and Adenovirus-Mediated p53 Gene Therapy for MDM2-Overexpressing Hepatocellular Carcinoma, J Radiat Res. 53(2):202-210, 2012.
  118. Hongkwan Park, Pyung-Hwan Kim, Taewon Hwang, Oh-Joon Kwon, Tae-Joon Park, Sung-Wook Choi, Chae-Ok Yun, Jung Hyun Kim, Fabrication of Cross-linked Alginate Beads Using Electrospraying for Adenovirus Delivery, International Journal of Pharmaceutics. 427(2):417-425, 2012. (Co-Corresponding author)
  119. De-Chao Yu, Jung-Sun Lee, Ji Young Yoo, Hyewon Shin, Hongxin Deng, Yuquan Wei, Chae-Ok Yun, Soluble vascular endothelial growth factor decoy receptor FP3 exerts potent antiangiogenic effects, Molecular Therapy, 20(5):938-947, 2012 (Corresponding Author).
  120. Bu-Nam Jeon, Min-Kyeong Kim, Won-Il Choi, Dong-In Koh, Sung-Yi Hong, Kyung-Sup Kim, Minjung Kim, Chae-Ok Yun, Juyong Yoon, Kang-Yell Choi, Kyung-Ryul Lee, Kenneth P. Nephew, and Man-Wook Hur, KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A, Cancer Research. 72(5):1137-48, 2012.
  121. Taeyoung Koo, Il-Kyu Choi, Minjung Kim, Jungho Kim, and Chae-Ok Yun, Negative regulation-resistant p53 variant enhances oncolytic adenoviral gene therapy, Human Gene Therapy, 23(6):609-622, 2012 (Corresponding Author).
  122. Joung-Woo Choi, Jung-Sun Lee, Sung Wan Kim, and Chae-Ok Yun, Evolution of oncolytic adenovirus for cancer treatment, Advanced Drug Delivery Reviews, Invited Review, 64:720-729, 2012 (Corresponding Author).
  123. Jaesung Kim, Pyung-Hwan Kim, Hye Yeong Nam, Jungsun Lee, Chae-Ok Yun, and Sung Wan Kim, Linearized oncolytic adenoviral plasmid DNA delivered by bioreducible polymers, Journal of Controlled Release, 158:451–460, 2012. (Co-Corresponding author)
  124. Jaesung Kim, Pyung-Hwan Kim, Sung Wan Kim, and Chae-Ok Yun, Enhancing the therapeutic efficacy of adenovirus in combination with biomaterials, Biomaterials, review, 33:1838-1850, 2012 (Corresponding Author).
  125. K Lee, S-T Yun, C-O Yun, B-Y Ahn, and E-C Jo, S100A2 promoter-driven conditionally replicative adenovirus targets non-small-cell lung carcinoma, Gene Therapy, 19:967-977, 2012.
  126. Kyung-Ju Choi, Song-Nan Zhang, Il-Kyu Choi, Ji-Seong Kim, and Chae-Ok Yun, Strengthening of antitumor immune memory and prevention of thymic atrophy mediated by adenovirus expressing IL-12 and GM-CSF, Gene Therapy, 19(7):711-723, 2012 (Corresponding Author).